Review of Literature-Based Models for Skin and Eye Irritation and Corrosion
This report reviews the state-of-the-art of in silico and in vitro methods for assessing dermal and ocular irritation and corrosion. Following a general introduction, the current EU legislation for the classification and labelling of chemicals causing irritation and corrosivity is summarised. Then currently available non-animal approaches are reviewed. The main alternative approaches to assess acute local toxic effects are: a) in silico approaches, including SARs, QSARs and expert systems integrating multiple approaches; and b) in vitro test methods. In this review, emphasis is placed on literature-based (Q)SAR models for skin and eye irritation and corrosion as well as computer-based expert systems.
GALLEGOS SALINER Ana;
WORTH Andrew;
PATLEWICZ Grace;
2021-01-27
Publications Office of the European Union
JRC34532
1831-9424 (online),
EUR 22320 EN,
OP KJ-NA-22320-EN-N (online),
https://publications.jrc.ec.europa.eu/repository/handle/JRC34532,
10.2760/925662 (online),
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