Title: Review of Estimation Models for Biodegradation
Citation: QSAR & COMBINATORIAL SCIENCE vol. 27 no. 1 p. 32-40
Publication Year: 2008
JRC N°: JRC38163
ISSN: 1611-020X
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC38163
DOI: 10.1002/qsar.200710117
Type: Articles in periodicals and books
Abstract: This paper reviews the state-of-the-art of in silico methods for estimating the ready biodegradability of organic chemicals, and describes their (potential) applicability in the identification of chemicals that are persistent or very persistent in the environment, such as Persistent Organic Pollutants (POPs). The paper is based on an in-depth review performed by the European Chemicals Bureau (ECB) in support of the development of technical guidance for the implementation of the Registration, Evaluation, Authorisation of Chemicals (REACH) legislation, and is one of a series of mini-reviews in this journal. The review covers the most commonly used approaches for estimating the ready biodegradability of organic compounds, such as group contribution approaches, expert systems, probabilistic approaches, and hybrid approaches. The main sources of experimental data used to develop the models are also briefly described. The review concludes with an appraisal of the challenges of developing new models and some recommendations are made for further research.
JRC Directorate:Institute for Health and Consumer Protection Historical Collection

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