Radioimmunotherapy Is Effective Against High-Inoculum Cryptococcus Neoformans Infection in Mice and Does Not Select for Radiation-Resistant Cryptococcal Cells
We investigated the utility of radioimmunotherapy (RIT) in the treatment of experimental cryptococcal infection with high-inoculum and the possibility of RIT treatment selecting for fungal cells with radiation-resistant phenotypes. RIT reduced mortality in high-burden infections, and we found no evidence for the development of radiation-resistant cells.
BRYAN R. A.;
JIANG Z.;
HUANG X.;
MORGENSTERN Alfred;
BRUCHERTSEIFER Frank;
SELLERS R.;
CASADEVALL A.;
DADACHOVA E.;
2009-03-25
AMER SOC MICROBIOLOGY
JRC51183
0066-4804,
http://aac.asm.org,
https://publications.jrc.ec.europa.eu/repository/handle/JRC51183,
10.1128/AAC.01334-08,
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