Industrially manufactured titanium dioxide nanoparticles have been successfully radiolabelled with 48V by irradiation with a cyclotron-generated proton beam. Centrifugation tests showed that the 48V radio-labels were stably bound within the nanoparticle struc-
ture, while X-ray di®raction indicated that no major structural modi¯cations to the nanoparticles resulted from the proton irradiation. In vitro tests of the uptake of cold and radiolabelled nanoparticles using the human cell line Calu-3 showed no signi¯cant di®erence in
the uptake between both batches of nanoparticles. The uptake was quanti¯ed by Inductively Coupled Plasma Mass Spectrometry and high resolution °-ray spectrometry for cold and radiolabelled nanoparticles, respectively. These preliminary experiments indicate that al-
terations to the nanoparticles' properties introduced by proton bombardment can be controlled to a su±cient extent to allow their use for meaningful biological in-vestigations as radiotracers.
ABBAS Kamel;
CYDZIK Izabel;
DEL TORCHIO Riccardo;
FARINA Massimo;
FORTI Efrat;
GIBSON Peter;
HOLZWARTH Uwe;
SIMONELLI Federica;
KREYLING Wolfgang;
2010-10-19
SPRINGER
JRC52481
1388-0764,
https://publications.jrc.ec.europa.eu/repository/handle/JRC52481,
10.1007/s11051-009-9806-8,
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