Production and quality control of hight specific activity NCA Re-186 by Cyclotron irradiation

The applications of the radionuclides play a fundamental role in life sciences and in particular nowadays is becoming an indispensable branch of medical science with the radionuclides and labeled compounds production for medical applications. The Re-186g is a negatron-gamma emitter presently used in metabolic radiotherapy with optimal perspectives to be used in radioimmunotherapy too, thanks to its suitable nuclear properties: t1/2=90.64 h, main E¿=137 keV, Eß,max=1 071 keV, energy range suitable to treat cancers with dimensions from few mm to a few cm. The possibility to use this radionuclide for therapeutic purposes is linked to the possibility to increase its specific activity AS, substituting the common (n,¿) reaction on Re-185 with the (p,n) or (d,2n) cyclotron production on W-186 targets, followed by a selective radiochemical separation of the product in no-carrier-added form from both W target and Ta co-produced radionuclides.

GROPPI Flavia;  BONARDI Mauro;  MANENTI S.;  MARCHETTI M.;  GINI L.;  ABBAS Kamel;  HOLZWARTH Uwe;  SIMONELLI Federica; 

2010-01-28

JOHN WILEY & SONS LTD

JRC56478

0362-4803,   

https://publications.jrc.ec.europa.eu/repository/handle/JRC56478,