The need for toxicity assessment of industrially relevant nanoparticle materials implies that in vitro and in vivo biokinetics studies
are required. Radiolabelled nanoparticles are an excellent candidate for such biodistribution measurements and are also of high
interest for particle tracing and fate studies in other areas.
We describe here an external target system for direct activation of dry nanoparticle samples, with He or water cooling, which is
attached to an external beamline of the JRC Scanditronix MC-40 cyclotron at Ispra, Italy. A specially designed capsule is used to
hold several tens of mg of nanoparticle powder material to be irradiated. The target system design and cooling system is described,
and considerations regarding energy deposition, yield, heat transfer, radiation damage and radiotracer recoil are discussed.
ABBAS Kamel;
GIBSON Peter;
HORSTMANN Wijbe;
HOLZWARTH Uwe;
ARROJA Fernando;
SIMONELLI Federica;
KOZEMPEL Jan;
BULGHERONI Antonio;
CYDZIK Izabela;
2010-07-13
CHEMICKE LISTY
JRC59054
0009-2770,
http://www.chemicke-listy.cz/docs/full/2010_14_s198-s205.pdf,
https://publications.jrc.ec.europa.eu/repository/handle/JRC59054,
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