Title: Click chemistry on the surface of PLGA-b-PEG polymeric nanoparticles: a novel targetable fluorescent imaging nanocarrier
Authors: PUCCI AndreaLOCATELLI EricaPONTI JessicaUBOLDI ChiaraMOLINARI ValerioCOMES FRANCHINI Mauro
Citation: Journal of Nanoparticle Research vol. 15 no. 1818 p. 1-6
Publisher: Springer
Publication Year: 2013
JRC N°: JRC82096
ISSN: 1572-896X
URI: http://link.springer.com/article/10.1007%2Fs11051-013-1818-8#
http://publications.jrc.ec.europa.eu/repository/handle/JRC82096
DOI: 10.1007/s11051-013-1818-8
Type: Articles in periodicals and books
Abstract: In the quest for biocompatible nanocarriers for biomedical applications a great deal of effort is put on engineering the nanocomposites surface in order to render them specific to the particular purpose. We developed biocompatible PLGA-b-PEG-based nanoparticles carrying a double functionality (i.e. carboxylic and acetylenic) able to serve as flexible highly selective grafting centers for cancer diagnosis and treatment. As a proof of concept the nanocarrier was successfully functionalized with a tailored fluorescent molecule by means of click chemistry and with a targeting agent specific for Glioblastoma Multiforme via amidic bond formation.
JRC Directorate:Institute for Health and Consumer Protection Historical Collection

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