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|Title:||Click chemistry on the surface of PLGA-b-PEG polymeric nanoparticles: a novel targetable fluorescent imaging nanocarrier|
|Authors:||PUCCI Andrea; LOCATELLI Erica; PONTI Jessica; UBOLDI Chiara; MOLINARI Valerio; COMES FRANCHINI Mauro|
|Citation:||Journal of Nanoparticle Research vol. 15 no. 1818 p. 1-6|
|Type:||Articles in periodicals and books|
|Abstract:||In the quest for biocompatible nanocarriers for biomedical applications a great deal of effort is put on engineering the nanocomposites surface in order to render them specific to the particular purpose. We developed biocompatible PLGA-b-PEG-based nanoparticles carrying a double functionality (i.e. carboxylic and acetylenic) able to serve as flexible highly selective grafting centers for cancer diagnosis and treatment. As a proof of concept the nanocarrier was successfully functionalized with a tailored fluorescent molecule by means of click chemistry and with a targeting agent specific for Glioblastoma Multiforme via amidic bond formation.|
|JRC Directorate:||Institute for Health and Consumer Protection Historical Collection|
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