Click chemistry on the surface of PLGA-b-PEG polymeric nanoparticles: a novel targetable fluorescent imaging nanocarrier
In the quest for biocompatible nanocarriers for biomedical applications a great deal of effort is put on engineering the nanocomposites surface in order to render them specific to the particular purpose. We developed biocompatible PLGA-b-PEG-based nanoparticles carrying a double functionality (i.e. carboxylic and acetylenic) able to serve as flexible highly selective grafting centers for cancer diagnosis and treatment. As a proof of concept the nanocarrier was successfully functionalized with a tailored fluorescent molecule by means of click chemistry and with a targeting agent specific for Glioblastoma Multiforme via amidic bond formation.
PUCCI Andrea;
LOCATELLI Erica;
PONTI Jessica;
UBOLDI Chiara;
MOLINARI Valerio;
COMES FRANCHINI Mauro;
2014-01-15
Springer
JRC82096
1572-896X,
http://link.springer.com/article/10.1007%2Fs11051-013-1818-8#,
https://publications.jrc.ec.europa.eu/repository/handle/JRC82096,
10.1007/s11051-013-1818-8,
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