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|Title:||225Ac imaging of NK1-targeted α-particle for glioblastoma radiotherapy|
|Authors:||ABOU Diane; GUERRERO-CAZARES H; MINN Il; POMPER Martin; QUINONES-HINOJOSA Alfredo; MORGENSTERN Alfred; BACK Tom; HOBBS Robert F.; WAHL Richard; SGOUROS George|
|Citation:||JOURNAL OF NUCLEAR MEDICINE vol. 55 no. Supplement 1 p. 393|
|Publisher:||SOC NUCLEAR MEDICINE INC|
|Type:||Articles in periodicals and books|
|Abstract:||Treatments for glioblastoma (GB) are critically insufficient. We aim to develop an efficient therapy based on a molecularly-specific-delivery of the extremely potent long-lived α particle 225Ac. Substance P (SP) binds neurokinin receptors NK1, overexpressed in GB. Recently, targeted therapies using 90Y- or 213Bi-labeled SPs have emerged as potent options but are either toxic or insufficient. Via 225Ac-SP intracranial delivery, we intend to longitudinally treat GB and eradicate disseminated brain tumors.|
|JRC Directorate:||Nuclear Safety and Security|
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