Title: 225Ac imaging of NK1-targeted α-particle for glioblastoma radiotherapy
Authors: ABOU DianeGUERRERO-CAZARES HMINN IlPOMPER MartinQUINONES-HINOJOSA AlfredoMORGENSTERN AlfredBACK TomHOBBS Robert F.WAHL RichardSGOUROS George
Citation: JOURNAL OF NUCLEAR MEDICINE vol. 55 no. Supplement 1 p. 393
Publisher: SOC NUCLEAR MEDICINE INC
Publication Year: 2014
JRC N°: JRC88667
ISSN: 0161-5505
URI: http://jnumedmtg.snmjournals.org/cgi/content/meeting_abstract/55/1_MeetingAbstracts/393
http://publications.jrc.ec.europa.eu/repository/handle/JRC88667
Type: Articles in periodicals and books
Abstract: Treatments for glioblastoma (GB) are critically insufficient. We aim to develop an efficient therapy based on a molecularly-specific-delivery of the extremely potent long-lived α particle 225Ac. Substance P (SP) binds neurokinin receptors NK1, overexpressed in GB. Recently, targeted therapies using 90Y- or 213Bi-labeled SPs have emerged as potent options but are either toxic or insufficient. Via 225Ac-SP intracranial delivery, we intend to longitudinally treat GB and eradicate disseminated brain tumors.
JRC Directorate:Nuclear Safety and Security

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