The EURL ECVAM status report provides an update on the progress made in the development, validation and regulatory acceptance of alternative methods and approaches since the last report published in April 2013. It is informing on ongoing research and development activities, validation studies, peer reviews, recommendations, strategies and international acceptance of alternative methods and approaches. R&D activities are ongoing for the complex endpoints where the toxicological processes and the mechanistic understanding have not been sufficiently elucidated yet and for which 3Rs solutions are more difficult to find. On the other hand, good progress In the validation and regulatory acceptance is made in areas where non-animal alternative methods have been developed and validated and where the focus lies in an intelligent combination/ integration of the various non-animal approaches.

ZUANG Valerie;  DESPREZ Bertrand;  VIEGAS BARROSO Joao Filipe;  BERGGREN Elisabet;  BERNASCONI Camilla;  BESSEMS Joseph;  CASATI Silvia;  COECKE Sandra;  CORVI Raffaella;  GRIESINGER Claudius;  HALDER Maria Elisabeth;  JANUSCH ROI Annett;  LANDESMANN Brigitte;  MADIA Federica;  MILCAMPS Anne;  MUNN Sharon;  PRICE Anna;  PRIETO PERAITA Maria Del Pilar;  SCHAEFFER Michael Wilhelm;  WITTWEHR Clemens;  WORTH Andrew;  WHELAN Maurice; 

2014-07-21

Publications Office of the European Union

JRC90989

978-92-79-38865-1 (print),    978-92-79-38864-4,   

1018-5593 (print),    1831-9424 (online),   

EUR 26702,    OP LB-NA-26702-EN-C (print),    OP LB-NA-26702-EN-N (online),   

https://publications.jrc.ec.europa.eu/repository/handle/JRC90989,   

10.2788/8638 (print),    10.2788/86047 (online),