Small scale renal dosimetry for alpha particle radiopharmaceutical therapy of metastatic breast cancer with 225Ac-7.16.4

Metastatic disease requires a systemic approach to therapy. Alpha particle radiopharmaceutical therapy (Alpha-RPT) is a new modality that is figuring prominently in pre-clinical and clinical studies. 225Ac-7.16.4 for pulmonary metastases in a murine metastatic breast cancer model showed high therapeutic efficacy. Despite a low calculated absorbed dose to the whole kidney, renal toxicity was observed in the treated animals. Renal toxicity thresholds established by external beam and targeted radiopeptide therapy is 25-30 Gy. The purpose was to use histological and Alpha Camera images to determine the activity concentration and distribution for 225Ac-7.16.4 and unbound 213Bi at sub organ level. Alpha Camera imaging was performed for small scale dosimetry of the kidneys using a previously developed nephron-based dosimetry model.

JOSEFSSON Anders;  ZHU Charles;  PARK Sunju;  ABOU Diane;  SONG Hong;  HUSO D. L.;  BACK Tom;  BRUCHERTSEIFER Frank;  MORGENSTERN Alfred;  BOLCH Wesley;  SGOUROS George;  HOBBS Robert F.; 

2015-11-09

ELSEVIER SCIENCE INC

JRC95397

0360-3016,   

https://publications.jrc.ec.europa.eu/repository/handle/JRC95397,   

10.1016/j.ijrobp.2015.07.355,