Metastatic disease requires a systemic approach to therapy. Alpha particle radiopharmaceutical therapy (Alpha-RPT) is a new modality that is figuring prominently in pre-clinical and clinical studies. 225Ac-7.16.4 for pulmonary metastases in a murine metastatic breast cancer model showed high therapeutic efficacy. Despite a low calculated absorbed dose to the whole kidney, renal toxicity was observed in the treated animals. Renal toxicity thresholds established by external beam and targeted radiopeptide therapy is 25-30 Gy. The purpose was to use histological and Alpha Camera images to determine the activity concentration and distribution for 225Ac-7.16.4 and unbound 213Bi at sub organ level. Alpha Camera imaging was performed for small scale dosimetry of the kidneys using a previously developed nephron-based dosimetry model.
JOSEFSSON Anders;
ZHU Charles;
PARK Sunju;
ABOU Diane;
SONG Hong;
HUSO D. L.;
BACK Tom;
BRUCHERTSEIFER Frank;
MORGENSTERN Alfred;
BOLCH Wesley;
SGOUROS George;
HOBBS Robert F.;
2015-11-09
ELSEVIER SCIENCE INC
JRC95397
0360-3016,
https://publications.jrc.ec.europa.eu/repository/handle/JRC95397,
10.1016/j.ijrobp.2015.07.355,
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