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|Title:||Small scale renal dosimetry for alpha particle radiopharmaceutical therapy of metastatic breast cancer with 225Ac-7.16.4|
|Authors:||JOSEFSSON Anders; ZHU Charles; PARK Sunju; ABOU Diane; SONG Hong; HUSO D. L.; BACK Tom; BRUCHERTSEIFER Frank; MORGENSTERN Alfred; BOLCH Wesley; SGOUROS George; HOBBS Robert F.|
|Citation:||INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS vol. 93 no. 3S p. S149; 341|
|Publisher:||ELSEVIER SCIENCE INC|
|Type:||Articles in periodicals and books|
|Abstract:||Metastatic disease requires a systemic approach to therapy. Alpha particle radiopharmaceutical therapy (Alpha-RPT) is a new modality that is figuring prominently in pre-clinical and clinical studies. 225Ac-7.16.4 for pulmonary metastases in a murine metastatic breast cancer model showed high therapeutic efficacy. Despite a low calculated absorbed dose to the whole kidney, renal toxicity was observed in the treated animals. Renal toxicity thresholds established by external beam and targeted radiopeptide therapy is 25-30 Gy. The purpose was to use histological and Alpha Camera images to determine the activity concentration and distribution for 225Ac-7.16.4 and unbound 213Bi at sub organ level. Alpha Camera imaging was performed for small scale dosimetry of the kidneys using a previously developed nephron-based dosimetry model.|
|JRC Directorate:||Nuclear Safety and Security|
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