Title: Small scale renal dosimetry for alpha particle radiopharmaceutical therapy of metastatic breast cancer with 225Ac-7.16.4
Authors: JOSEFSSON AndersZHU CharlesPARK SunjuABOU DianeSONG HongHUSO D. L.BACK TomBRUCHERTSEIFER FrankMORGENSTERN AlfredBOLCH WesleySGOUROS GeorgeHOBBS Robert F.
Citation: INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS vol. 93 no. 3S p. S149; 341
Publisher: ELSEVIER SCIENCE INC
Publication Year: 2015
JRC N°: JRC95397
ISSN: 0360-3016
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC95397
DOI: 10.1016/j.ijrobp.2015.07.355
Type: Articles in periodicals and books
Abstract: Metastatic disease requires a systemic approach to therapy. Alpha particle radiopharmaceutical therapy (Alpha-RPT) is a new modality that is figuring prominently in pre-clinical and clinical studies. 225Ac-7.16.4 for pulmonary metastases in a murine metastatic breast cancer model showed high therapeutic efficacy. Despite a low calculated absorbed dose to the whole kidney, renal toxicity was observed in the treated animals. Renal toxicity thresholds established by external beam and targeted radiopeptide therapy is 25-30 Gy. The purpose was to use histological and Alpha Camera images to determine the activity concentration and distribution for 225Ac-7.16.4 and unbound 213Bi at sub organ level. Alpha Camera imaging was performed for small scale dosimetry of the kidneys using a previously developed nephron-based dosimetry model.
JRC Directorate:Nuclear Safety and Security

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