Non-Animal Methods in Science and Regulation

ZUANG, Valerie; BARROSO, João; BERGGREN, Elisabet; BOPP, Stephanie; BRIDIO, Sara; CASATI, Silvia; CORVI, Raffaella; DECEUNINCK, Pierre; FRANCO, Antonio; GASTALDELLO, Annalisa; LANGEZAAL, Ingrid; MALINOWSKA, Julia; MENNECOZZI, Milena; MILCAMPS, Anne; MUNN, Sharon; PIERGIOVANNI, Monica; PRIETO-PERAITA, Pilar; SAMPANI, Stavroula; VALSESIA, Debora; WHELAN, Maurice; WITTWEHR, Clemens; WORTH, Andrew

doi:10.2760/44273

2024Science for policyHealth and consumer protection

EURL ECVAM Status Report 2023

The 2023 EURL ECVAM Status Report outlines research and development activities, along with initiatives that foster the implementation and utilisation of non-animal methods and approaches in scientific research and regulation. The Three Rs principle, which advocates for Replacement, Reduction, and Refinement of animal use in basic, applied, and translational research, as well as for regulatory purposes, is firmly established in EU legislation, with the ultimate goal of fully replacing animal testing.
New approach methodologies encompassing a range of innovative technologies, including in vitro methods employing 3D tissues and cells, organ-on-chip technologies, computational models (including machine learning and artificial intelligence), and 'omics (transcriptomics and metabolomics), are developed, evaluated, and integrated into assessment frameworks in order to enhance the efficiency and effectiveness of hazard and risk assessment of chemicals and products across various regulatory contexts. Furthermore, substantial efforts are directed at promoting the development and utilisation of non-animal approaches in fundamental and applied research, where the majority of animal testing occurs, as well as for educational purposes. The achievements and accomplishments documented in this report are the culmination of collaborative efforts with EURL ECVAM's dedicated partners and stakeholders.

2024-03-12

Publications Office of the European Union

JRC136460

978-92-68-11755-2 (online) , 978-92-68-11756-9 (print)

1831-9424 (online) , 1018-5593 (print)

EUR 31819 EN , OP KJ-NA-31-819-EN-N (online) , OP KJ-NA-31-819-EN-C (print)

https://publications.jrc.ec.europa.eu/repository/handle/JRC136460

10.2760/44273 (online) , 10.2760/05390 (print)

Language	Citation
ENG	Zuang, V., Barroso, J., Berggren, E., Bopp, S., Bridio, S., Casati, S., Corvi, R., Deceuninck, P., Franco, A., Gastaldello, A., Langezaal, I., Malinowska, J., Mennecozzi, M., Milcamps, A., Munn, S., Piergiovanni, M., Prieto-Peraita, P., Sampani, S., Valsesia, D., Whelan, M., Wittwehr, C. and Worth, A., Non-Animal Methods in Science and Regulation, Publications Office of the European Union, Luxembourg, 2024, doi:10.2760/44273, JRC136460.

Non-Animal Methods in Science and Regulation

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