2023-2024 Report of the Society for the Advancement of AOPs Knowledgebase Interest Group
The Society for the Advancement of AOPs Knowledgebase Interest Group (SKIG) is a vibrant assembly of more than 40 international experts focused on advancing the Adverse Outcome Pathways (AOP) framework. SKIG operates through regular online meetings, where two or three presentations per session—followed by lively Q&A interactions—delve into both technical and scientific topics critical to the AOP domain, with a particular focus on AOP-Wiki related issues. Presentations cover a broad spectrum of subjects, such as ontology-based harmonization, AI tools for AOP development, the integration of omics data, incorporating temporal aspects into AOPs, automated access to AOP-Wiki contents, the role of physiological maps and other approaches in establishing biological relevance, and many more. This caters to a diverse audience of scientists, regulators, and policymakers, and this dynamic approach allows readers to engage with specific subjects of interest rather than following a chronological sequence when perusing this report. The document also offers a concise summary of practical adaptations implemented in the AOP-Wiki following meeting discussions. Covering the meetings held in 2023 and 2024, the report reflects SKIG's ongoing contributions and indicates that the group will continue to operate in 2025 and beyond. SKIG's work to foster the development and application of AOPs is pivotal in supporting the European Union's policy on the protection of animals used for scientific purposes (Directive 2010/63/EU) and the European Commission’s Roadmap towards phasing out animal testing for chemical safety assessments.
WITTWEHR Clemens;
AUDOUZE Karine;
BURGDORF Tanja;
CLERBAUX Laure-Alix;
COEREK Emre;
DEMUYNCK Emmanuel;
EXNER Thomas;
FILIPOVSKA Julija;
FRITSCHE Ellen;
GERIS Liesbet;
HENCH Virginia;
JELIAZKOVA Nina;
KARSCHNIK Travis;
KUCHOVSKA Eliska;
MAIA LADEIRA Luiz Carlos;
MALINOWSKA Julia;
MARINOV Evgeni;
MARTENS Marvin;
MERTENS Birgit;
NYMARK Penny;
SCHAFFERT Alexandra;
STAUMONT Bernard;
TANABE Shihori;
TOLLEFSEN Knut Erik;
VILLENEUVE Daniel L.;
VIVIANI Barbara;
2025-04-03
Publications Office of the European Union
JRC140403
978-92-68-25041-9 (online),
1831-9424 (online),
EUR 40242,
OP KJ-01-25-121-EN-N (online),
https://publications.jrc.ec.europa.eu/repository/handle/JRC140403,
10.2760/7749010 (online),
